Multi-objective T-S fuzzy control of Covid-19 spread model: An LMI approachResearch article Published on 2023-01-012022-10-05 Journal: Biomedical Signal Processing and Control [Category] 변종, [키워드] Analysis approach approach coronavirus disease Covid 19 model hazard increase in Intervention Linear matrix inequalities (LMIs) mathematical Multi objective controller outbreak regulator Robust T-S fuzzy controller Spread suggested [DOI] 10.1016/j.bspc.2022.104107 [Article Type] Research article
A Meta-summary and Bioinformatic Analysis Identified Interleukin 6 as a Master Regulator of COVID-19 Severity BiomarkersResearch article Published on 2022-11-012022-10-05 Journal: Cytokine [Category] 바이오마커, 임상, 진단, 치료기술, [키워드] addition approach Bioinformatic Bioinformatics analysis Biomarker Biomarkers candidate Compound conserved COVID-19 COVID-19 disease COVID-19 disease severity COVID-19 severity Cytokine storm Cytokines dataset datasets disease severity enriched biological processe extreme highlight Identified identify IL6 immunological reaction include Inflammatory biomarker Inflammatory response interleukin 6 Isolation neurological Patient physiological system Prognosis Prognostic markers progression Protein proteomics regulator rising robust screening methods severity therapeutic approach Therapeutic approach treating COVID-19 Treatment upstream validation study [DOI] 10.1016/j.cyto.2022.156011 [Article Type] Research article
Geographical distribution of cystic fibrosis carriers as population genetic determinant of COVID-19 spread and fatality in 37 countries37개국에서 COVID-19 확산 및 사망률의 인구 유전적 결정인자인 낭포성 섬유증 보균자의 지리적 분포Article Published on 2022-09-012022-09-11 Journal: The Journal of Infection [Category] Fulltext, MERS, 변종, 유전자 메커니즘, 진단, [키워드] affected Cancer carrier carriers Case fatality rate CF carriers CFR CFTR Conductance conducted correlated country COVID-19 Cystic cystic fibrosis determine distribution ecological Ecological study Factor fatality fibrosis Genetic genetics geographical distribution heterogeneity higher risk Host Indicator Mortality multivariate Older pandemic pathogenic variant pathogenicity performed Population genetics positively correlated Prevalence Rate Regression model regulator respiratory tract infection Respiratory tract infections SARS-CoV-2 SARS-CoV-2. severe COVID-19 shown significantly Spread subject susceptible undergo Variability Weighting [DOI] 10.1016/j.jinf.2022.06.006 PMC 바로가기 [Article Type] Article
A model for network-based identification and pharmacological targeting of aberrant, replication-permissive transcriptional programs induced by viral infection바이러스 감염에 의해 유도된 비정상적인 복제 허용 전사 프로그램의 네트워크 기반 식별 및 약리학적 표적화 모델Article Published on 2022-07-192022-09-11 Journal: Communications Biology [Category] COVID19(2023년), SARS, 신약개발, 유전자 메커니즘, 치료제, [키워드] activate Analysis Cell cell viability determinant drug drugs targeting effective epithelial cell epithelial cells functional gene expression signature Host host cell identify inactivation induce infected cell infected cells Interaction mechanism of action methodology pathogen pharmacological phenotypic physical predicted Protein reduction regulator Replication representing repressed SARS-CoV-2 SARS-CoV-2 proteins SARS-CoV-2 replication therapy transcriptional treated viability viral infection virus replication without affecting [DOI] 10.1038/s42003-022-03663-8 PMC 바로가기 [Article Type] Article
Polymorphisms in ACE, ACE2, AGTR1 genes and severity of COVID-19 diseaseACE, ACE2, AGTR1 유전자 및 COVID-19 질병의 중증도의 다형성Research Article Published on 2022-02-042022-09-10 Journal: PLoS ONE [Category] COVID19(2023년), MERS, SARS, 변종, [키워드] 95%CI ACE ACE gene ACE2 ACE2 protein admitted to ICU age AGTR1 Analysis analyzed angiotensin association Cancer Cell Clinical course collected Comorbidities Comorbidity Course COVID-19 disease COVID-19 infection COVID-19 patient COVID-19 patients death death group Deceased demonstrated diabetes disease distribution evidenced exaggerated inflammatory response expected G/A Gender Genetic Genetic variant Genotype greater Hardy-Weinberg equilibrium Hospitalization Hospitalized Human hypertension I/D ICU increased risk increased the risk Infection inheritance intensive care unit lead Lung disease male marker modulate multivariable multivariable analysis nucleotide obesity Older age Outpatient outpatients patients with comorbidities patients with COVID-19 produced protector recessive model regulator Renin renin-angiotensin system Result risk rs1978124 rs2285666 SARS-CoV-2 SARS-CoV-2 virus selected severity severity of COVID-19 Severity of disease Single nucleotide polymorphism single nucleotide polymorphisms SNP SNPs susceptibility susceptibility to infection the cell the disease the severity group virus while [DOI] 10.1371/journal.pone.0263140 PMC 바로가기 [Article Type] Research Article
The Candida albicans Cdk8-dependent phosphoproteome reveals repression of hyphal growth through a Flo8-dependent pathway칸디다 알비 칸스 CDK8- 의존적 포스 포 단백체는 FLO8- 의존적 경로를 통한 균사 성장의 억압을 나타낸다.Research Article Published on 2022-01-042022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] acquisition activities Affect Amino acid amino acids analyses ATP Candida Candida albican Candida albicans Cdk8 cell interactions cellular conditions dead dependent on drug resistance functional growth hypha hyphal identify Immune cell Impact inactivation increased expression inhibited Interaction interactions involved leads mediator Mediator complex medium member metabolism modulate Morphological morphological changes morphology mutant Mutation nutrient pathway performed phenotype Phenotypes phosphoproteome phosphorylation site physiological promoted Protein Protein phosphorylation sites Rapid reduced regulate Regulation regulator replaced reveal Serine shown Steady state strain substrate target targets the strongest These data threonine Transcription transcription factor transcriptional transcriptomics variant virulence was used [DOI] 10.1371/journal.pgen.1009622 PMC 바로가기 [Article Type] Research Article
What influences attitudes about artificial intelligence adoption: Evidence from U.S. local officialsResearch Article Published on 2021-10-202022-10-28 Journal: PLoS ONE [Category] Coronavirus, MERS, SARS, [키워드] Algorithms Analysis approval autonomous correlated COVID-19 pandemic expressed facial Gender Government greater influence information knowledge Local optimism Quantitative Rapid Regulation regulator significantly more Support Surveillance The United States trade-off unique variety [DOI] 10.1371/journal.pone.0257732 PMC 바로가기 [Article Type] Research Article
The proximal proteome of 17 SARS-CoV-2 proteins links to disrupted antiviral signaling and host translation17개의 SARS-CoV-2 단백질의 근위 프로테옴은 항바이러스 신호 전달 및 숙주 번역을 방해합니다.Research Article Published on 2021-10-012022-09-10 Journal: PLoS Pathogens [Category] MERS, SARS, 변종, 유전자 메커니즘, [키워드] Activation antiviral signaling association atlas Card cleavage complex coronavirus Coronaviruses COVID-19 severity CWC22 database Factor FANCD2 Fluorescence functional Host host protein host proteins human cell human protein identify IFNB1 Impact inhibited inhibitor innate immune interferon signaling M protein MAVS membranes nsp1 nsp5 ORF6 Pathogenesis pathogenic coronavirus pathogenic mechanism pathogenic mechanisms pathogenicity peptide peptide sequences promote promoter protease Protein protein translation Proteins proteome proteomics proximal public health threat regulator Regulatory resource RIG-I SARS-CoV-2 SARS-CoV-2 biology SARS-CoV-2 protein SARS-CoV-2 proteins SARS-CoV-2 viral sequence Signaling subcellular target the SARS-CoV-2 translation translation initiation Transport TRIM4 variant Viral Viral protein Viral proteins [DOI] 10.1371/journal.ppat.1009412 PMC 바로가기 [Article Type] Research Article
Pan-Cancer Analysis of Genomic and Prognostic Characteristics Associated With Coronavirus Disease 2019 RegulatorsMedicine Published on 2021-08-112022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] ACE1 ACE2 AGT analysis analyzed Angiotensin-converting enzyme angiotensin-converting enzyme 2 approach Atla Biomarkers Cancer cancers Clinical characteristics coronavirus disease correlated COVID-19 COVID-19 regulators database drug drugs targeting evaluated expression level genetic alteration genetic alterations genomic alteration information Interaction mechanism Methylation outcomes Pan-cancer Pathways Patient portal potential mechanism Prognosis prognostic receptor regulator response RNA-seq data sensitivity serine protease significantly single nucleotide SLC6A19 solid tumor solid tumors Therapeutics TMPRSS2 tumorigenesis Variation widespread [DOI] 10.3389/fmed.2021.662460 PMC 바로가기 [Article Type] Medicine
Long Noncoding RNAs as Emerging Regulators of COVID-19COVID-19의 새로운 조절자로서의 긴 비코딩 RNAReview Published on 2021-08-022022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 바이오마커, 유전자 메커니즘, 치료제, [키워드] (Tocilizumab) acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 Antiviral antiviral immune response antiviral immune responses antiviral role biological processe biological processes cellular changes in Clinical treatment coronavirus disease Coronavirus disease 2019 Coronavirus-2 COVID-19 COVID-19 treatment death Dexamethasone disease drug Evidence expression glucocorticoid Glucocorticoids help Host host transcriptome immune dysfunction Immune escape immune responses incidence rate indicate Infection Inflammatory response inhibiting interferons involved lncRNA lncRNAs Long long noncoding RNA mechanisms monoclonal antibodies monoclonal antibody Occurrence pandemic pathology regulate Regulation regulator Research respiratory resulting RNA SARS-CoV-2 SARS-COV-2 infection Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 Spread subsequent therapeutic thrombosis Tocilizumab Transcriptome Treatment type I interferon type I interferons up-regulate Viral viral gene viral genes viral infections viral replication virus infection virus infections [DOI] 10.3389/fimmu.2021.700184 PMC 바로가기 [Article Type] Review